VITAMIN K2... The new Vitamin D, B12, C?

[Joelseff]

some, but apparently both Vit C and steroids by themselves have an impact on sepsis.

From what I read on this, sepsis depletes Ascorbic Acid so I see the need to replete Vit C.

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[MediMike]

There have been a multitude of studies on the efficacy (or lack thereof) of steroids in sepsis with the majority of ICUs continuing their use in septic shock.

The numbers purported by Marik et al in his original HAT article in CHEST blows any regular steroid regimen out of the water, and continues to do so with continued case reports. There is a physiologic basis for septic patients being deplete in VitC and for VC's role in pressor responsiveness with quite a few trials demonstrating the same.

Will be great to see a couple big ones coming through this year though, think Emory and maybe Duke(?) should be starting their analysis this spring.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206928/

Anyways, sorry to derail from the K2 thing! Carry on!

[EMEDPA]

seems to me like we should be using more than 1.5 gm of vit c, but I have been using that as that is the protocol dose.

[NeoTrion]

To be honest they did not talk about taking levels.  They were all about just giving a low level supplement indefinitely.  The advise starting every patient on low level vitamin ADEK2.  It was mainly recommended to have this replacement to decrease the risk of Osteoporosis and Heart disease.  This is recommended in Japan due to the findings of several trials that dealt particularly in postmenopausal women.  It is basically the same information that is coming out about Vitamin D and how some studies feel that a more optimal level is above 65 now.  Not saying I am a believer, but it I do keep it in the back of the brain pan.