polarbebe Posted May 22, 2014 Share Posted May 22, 2014 Using this where you work to rule out low risk PE in the elderly? http://www.ncbi.nlm.nih.gov/m/pubmed/24643601/ Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. AuthorsRighini M, et al. Show all Journal JAMA. 2014 Mar 19;311(11):1117-24. doi: 10.1001/jama.2014.2135. Affiliation Erratum in JAMA. 2014 Apr 23-30;311(16):1694. Abstract IMPORTANCE: D-dimer measurement is an important step in the diagnostic strategy of clinically suspected acute pulmonary embolism (PE), but its clinical usefulness is limited in elderly patients. OBJECTIVE: To prospectively validate whether an age-adjusted D-dimer cutoff, defined as age × 10 in patients 50 years or older, is associated with an increased diagnostic yield of D-dimer in elderly patients with suspected PE. DESIGN, SETTINGS, AND PATIENTS: A multicenter, multinational, prospective management outcome study in 19 centers in Belgium, France, the Netherlands, and Switzerland between January 1, 2010, and February 28, 2013. INTERVENTIONS: All consecutive outpatients who presented to the emergency department with clinically suspected PE were assessed by a sequential diagnostic strategy based on the clinical probability assessed using either the simplified, revised Geneva score or the 2-level Wells score for PE; highly sensitive D-dimer measurement; and computed tomography pulmonary angiography (CTPA). Patients with a D-dimer value between the conventional cutoff of 500 µg/L and their age-adjusted cutoff did not undergo CTPA and were left untreated and formally followed-up for a 3-month period. MAIN OUTCOMES AND MEASURES: The primary outcome was the failure rate of the diagnostic strategy, defined as adjudicated thromboembolic events during the 3-month follow-up period among patients not treated with anticoagulants on the basis of a negative age-adjusted D-dimer cutoff result. RESULTS: Of the 3346 patients with suspected PE included, the prevalence of PE was 19%. Among the 2898 patients with a nonhigh or an unlikely clinical probability, 817 patients (28.2%) had a D-dimer level lower than 500 µg/L (95% CI, 26.6%-29.9%) and 337 patients (11.6%) had a D-dimer between 500 µg/L and their age-adjusted cutoff (95% CI, 10.5%-12.9%). The 3-month failure rate in patients with a D-dimer level higher than 500 µg/L but below the age-adjusted cutoff was 1 of 331 patients (0.3% [95% CI, 0.1%-1.7%]). Among the 766 patients 75 years or older, of whom 673 had a nonhigh clinical probability, using the age-adjusted cutoff instead of the 500 µg/L cutoff increased the proportion of patients in whom PE could be excluded on the basis of D-dimer from 43 of 673 patients (6.4% [95% CI, 4.8%-8.5%) to 200 of 673 patients (29.7% [95% CI, 26.4%-33.3%), without any additional false-negative findings. CONCLUSIONS AND RELEVANCE: Compared with a fixed D-dimer cutoff of 500 µg/L, the combination of pretest clinical probability assessment with age-adjusted D-dimer cutoff was associated with a larger number of patients in whom PE could be considered ruled out with a low likelihood of subsequent clinical venous thromboembolism. Link to comment Share on other sites More sharing options...
Moderator True Anomaly Posted May 24, 2014 Moderator Share Posted May 24, 2014 Good article- seems to be a well done study that fills in a lot of holes in the literature. I like how they even note the comparison of using 6 different D-dimer assays were pretty equal in their results. To answer your question, we're not using any age-related cutoffs as of yet, and I haven't heard anyone talk about this article yet. My thinking is our institution would want to see a US-based multicenter prospective trial be done to help validate these results. I'd also be interested to see what Jeff Kline, one of the foremost PE/DVT experts in the US, has to say about this- he has advocated before for D-dimer cutoffs based on the trimester of pregnancy. Link to comment Share on other sites More sharing options...
jen0508 Posted July 15, 2014 Share Posted July 15, 2014 Several of my SP's are using this now. Personally i have not used this yet Link to comment Share on other sites More sharing options...
LoRezSkyline Posted July 15, 2014 Share Posted July 15, 2014 I'd also be interested to see what Jeff Kline, one of the foremost PE/DVT experts in the US, has to say about this Ask, and ye shall receive... http://www.annemergmed.com/article/S0196-0644(13)01712-5/pdf If you're on Twitter, Kline's always dropping PE/DVT pearls on there - great one to follow, @klinelab. His latest project below - he & others are trying to advocate for a standardized, across-the-board dimer instead of the myriad tests/ranges we have now. https://twitter.com/klinelab https://twitter.com/klinelab/status/485144778846511104 Link to comment Share on other sites More sharing options...
Moderator True Anomaly Posted July 15, 2014 Moderator Share Posted July 15, 2014 Thanks LoRez! Very helpful. Looks like that particular method still needs further study, but overall looking good Link to comment Share on other sites More sharing options...
medic25 Posted July 15, 2014 Share Posted July 15, 2014 This was discussed on the most recent EM:RAP. A good point is that you should have your institution develop a formal policy recognizing the age-adjusted standards. You'll have trouble defending yourself if the patient bounced back with a PE (it happens) and their d-dimer was positive according to your lab, even if it was lower than the age-adjusted figure. Link to comment Share on other sites More sharing options...
LoRezSkyline Posted July 17, 2014 Share Posted July 17, 2014 ...and then there's this, which suggests this one might not quite be ready for prime-time just yet??? http://rebelem.com/update-age-adjusted-d-dimer/ agreed re: the above post, no way am i instituting this in my practice until it's a well-established institutional policy!!! Link to comment Share on other sites More sharing options...
Moderator EMEDPA Posted July 17, 2014 Moderator Share Posted July 17, 2014 also remember the limitations of the d-dimer. it measures ACUTE products of coagulation. if someone has managed to survive with their huge PE for 2 weeks and not died their D-Dimer may be normal. we were within 5 minutes of d/c ing a guy in his 40s with chest pain from our obs unit with nl ekgs, nl enzymes, nl d-dimer, nl cxr, nl metabolic workup including tsh, and nl treadmill until one of the docs recognized that even while asleep this guy had a resting tachycardia of around 105 that had persisted for >24 hrs. CTA showed massive b/l PEs. we covered his pain with narcs, toradol, etc while in the obs unit prior to his dx, but because his underlying physical condition was excellent he never had a poor sat, got tachypneic, or did the nl things folks do who have big PEs. Link to comment Share on other sites More sharing options...
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