GetMeOuttaThisMess Posted May 31, 2017 Share Posted May 31, 2017 I don't remember where I read this last week (may have been in my monthly abstracts) but I thought that this was a neat pearl. To determine how long it takes for a med to be loaded into the system, and also how long until it clears your system, utilize the "Rule of 5" (not to be confused with the "Rules of 2" for RAD). Take your medication half-life and multiple x5. This will tell you when you medication in time is loaded. Same rule for when medication clears your system after completing final dosing. Example: Eliquis has a half-life of 12 hours. 12x5=60 hrs. Pt. is anti-coagulated in almost 2 1/2 days. Others may have already been aware of this pearl but it was news to me. Back to our regularly scheduled programming... Link to comment Share on other sites More sharing options...
airslant Posted May 31, 2017 Share Posted May 31, 2017 Anti-coagulated in 2.5 days and then after the last dose they are still anti-calculated for 2.5 days or you can consider it out of their system in 2.5 days? Sent from my Pixel XL using Tapatalk Link to comment Share on other sites More sharing options...
polarbebe Posted May 31, 2017 Share Posted May 31, 2017 Good rule of thumb. When considering clearance also bear in mind to take in a patient's renal and/or hepatic function, volume of distribution and whether the drug has active metabolites (some of my ICU patients will stay sedated for weeks after a versed gtt or a patient who is ESRD will remain therapeutic on vanc until their next HD session vs a normal steady state after 4-5 doses in a patient with normal renal function). Link to comment Share on other sites More sharing options...
GetMeOuttaThisMess Posted May 31, 2017 Author Share Posted May 31, 2017 Anti-coagulated in 2.5 days and then after the last dose they are still anti-calculated for 2.5 days or you can consider it out of their system in 2.5 days? Sent from my Pixel XL using Tapatalk In "normal" circumstances yes. See above for extenuating circumstances. Link to comment Share on other sites More sharing options...
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