badtriangle Posted January 27, 2016 Share Posted January 27, 2016 Anyone ever seen this? know the cause? Performing TKA and upon opening the retinaculum, we could see that all the edges of the peri-articular cartilage were blue or blackish in color. The cancellous bone also had a "dirty" or mucky brown to dirty yellow appearance. I have never seen this so did some searching. Found a japanese article that called it black bone and attributed it to minocycline use and it was also seen to stain the periodontal tissues. I remembered from pharm that the tetracyclines can stain young children's teeth and therefore not given, but had never heard of the periarticular areas being stained as well. he states he doesn't take -cyclines on a regular basis and isn't currently on any supplements. Link to comment Share on other sites More sharing options...
goose37 Posted February 5, 2016 Share Posted February 5, 2016 Have actually seen something similar in the shoulder. Thought it was necrosis but pathology informed us that blood supply was intact. Did notice increased hemosiderin deposits, so we assumed it was from a previous hematoma that was present. Interesting none the least. Link to comment Share on other sites More sharing options...
nellaone Posted February 17, 2016 Share Posted February 17, 2016 Minocycline. It is a drug routinely used for acne and rheumatoid arthritis. It causes bone to become pigmented, usually discovered during a total joint surgery. Freaked me out the first time I saw it also. There is an article written by Dale N. Reed, et al titled, "Minocycline-induced black bone disease encountered during total knee arthroplasty" published in Orthopedics Journal May 2012. Link to comment Share on other sites More sharing options...
Reality Check 2 Posted February 17, 2016 Share Posted February 17, 2016 Tetracycline was the most popular acne drug in the 60s and 70s. Moms who took it had kids whose teeth had dark lines through them. I grew up with 6 kids from one family who all had the same thing. I haven't ever seen it in bone but have seen tons of dental issues from the "cycline" family. Now, the concern is Crohns and CDiff for long term use of these drugs. There is no such thing as a free lunch…... Link to comment Share on other sites More sharing options...
badtriangle Posted February 22, 2016 Author Share Posted February 22, 2016 Update: After not seeing minocycline on his med rec, I questioned the patient and he admitted that he had used it for a long time, but forgot to mention it. Oddly enough, I had always noticed a blue/grey hue to his skin also. So, minocycline FTW Link to comment Share on other sites More sharing options...
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