Anaphylaxis is more than a medical term, but is a life changer and a very real medical emergency. I cringe when I consider that some of my colleagues have given a kid an injection of penicillin and have not waited 30 minutes for the possibility of a reaction. I saw my sister have this reaction when I was a kid, and her angioedema made her look like a Jack-o-lantern on Halloween night. She was fortunately brought to the hospital immediately and she responded to the epinephrine. It is important for us to consider the collateral damage done to the parents and siblings of someone that has an anaphylactic reaction to a medication or shellfish, iodine or any other agent including middle and upper aged people placed on an Ace inhibitor.